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Table
of Contents > Depletions
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Antacids, Aluminum, Calcium, and ...
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| Antacids |
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| Aluminum, Calcium, and
Magnesium-Containing Preparations |
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 | Aluminum Hydroxide
and Magnesium Hydroxide
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 | Calcium Carbonate
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 | Calcium Carbonate and
Magnesium Hydroxide
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| Depletions |
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| Calcium |
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Osteoporosis (bone loss) is the primary disease
associated with long-term calcium deficiency; it may be
associated with bone pain and spinal deformity. Depleted
levels can also cause muscle cramps, irregular heartbeat,
and depression.
Note: Calcium carbonate antacids may elevate calcium
levels, depending upon the circumstances of use. Consult
your doctor.
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| Copper |
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Although copper deficiency is rare, signs and symptoms
of long-term depletion of copper include anemia, changes
in the structure and appearance of hair, heart damage,
growth retardation, impaired bone formation, osteoporosis
(bone loss), and emphysema (lung disease).
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| Iron |
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Depleted levels of iron may lead to anemia and weakened
immune function. In the event of anemia, symptoms include
dizziness, fatigue, shortness of breath, pale skin color,
and possibly irregular heartbeat.
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| Magnesium |
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Magnesium deficiency affects calcium and vitamin D
levels in the body and may be associated with muscle
cramps, heart irregularities, high blood pressure,
diabetes, and osteoporosis (bone loss).
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| Phosphorus |
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Although phosphorus deficiency is rare, long-term low
levels are associated with muscle weakness, bone pain,
mental confusion, anorexia, anemia, increased
susceptibility to infection, respiratory difficulties,
seizures, and even death.
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| Potassium |
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Symptoms of potassium deficiency include loss of
appetite, nausea, drowsiness, feelings of apprehension,
excessive thirst, irrational behavior, fatigue, muscle
pain and weakness (usually of the lower limbs); severe
cases may lead to irregular heartbeat.
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| Zinc |
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Signs and symptoms of zinc deficiency include loss of
appetite or sense of taste, growth retardation, skin
changes, and increased susceptibility to infection.
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| Editorial Note |
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The selected depletions information presented here
identifies some of the nutrients that may be depleted by
certain medications. The signs and symptoms associated
with nutrient deficiency may also indicate conditions
other than nutrient deficiency. If you are experiencing
any of the signs or symptoms mentioned, it does not
necessarily mean that you are nutrient deficient. Nutrient
depletion depends upon a number of factors, including your
medical history, diet, and lifestyle as well as the length
of time you have been taking the medication. Please
consult your healthcare provider; he or she can best
assess and address your individual healthcare needs, and
determine if you are at risk for nutrient depletions from
these medications as well as others not listed here.
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| Supporting Research |
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Ames BN. Micronutrient deficiencies: A major cause of
DNA damage. Ann NY Acad Sci. 2000;889:87-106.
Cashman K, Flynn A. Optimal nutrition: calcium,
magnesium and phosphorus. Proc Nutr Soc.
1999;58:477-487.
Covington T, ed. Nonprescription Drug Therapy
Guiding Patient Self-Care. St Louis, MO: Facts and
Comparisons;
1999:467-545.
Falchuk KH. Disturbances in Trace Elements. In: Fauci
A, Braunwald E, Isselbacher KJ, et al, eds. Harrison's
Principles of Internal Medicine. 14th ed. New York,
NY: McGraw-Hill Companies Health Professional Division;
1998:490-491.
Faloon, WW. Drug production of intestinal
malabsorption. N.Y. State J. Med. 70:2, 189, 1970.
Hambidge M. Human zinc deficiency. J Nutr.
2000;130(5S Suppl):1344S-1349S.
National Research Council. Recommended Dietary
Allowances. 10th ed. Washington, DC: National Academy
Press; 1989.
Potts JT. Diseases of the parathyroid gland and other
hyper- and hypocalcemic disorders. In: Fauci AS, Braunwald
E, Isselbacher KJ, et al, eds. Harrison's Principles of
Internal Medicine. 14th ed. New York:
McGraw-Hill Companies Health Professional Division;
1998:2241.
Roe DA. Diet and Drug Interactions. New York,
Van Nostrand Reinhold, pp. 85-86, 1989.
Spencer, H. et al. Effect of small amounts of antacids
on calcium, phosphorus, and fluoride metabolism in man. Gastroenterol.
68:990, 1975.
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| Review Date: October
2000 |
Reviewed By: All
depletions monographs have been reviewed by a team of
experts including Derrick M. DeSilva, Jr., MD, Raritan Bay
Medical Center, Perth Amboy, NJ; Jacqueline A. Hart, MD,
Department of Internal Medicine, Newton-Wellesley
Hospital, Harvard University and Senior Medical Editor,
A.D.A.M., Inc., Boston, MA; John Hinze, PharmD, NMD,
Woodbine, IA; Ruth Marlin, MD, Medical Director and
Director of Medical Education, Preventive Medicine
Research Institute, Sausalito, CA; Brian T Sanderoff, PD,
BS in Pharmacy, Clinical Assistant Professor, University
of Maryland School of Pharmacy; President, Your
Prescription for Health, Owings Mills, MD; Leonard
Wisneski, MD, FACP, George Washington University,
Rockville, MD; Ira Zunin, MD, MPH, MBA, President and
Chairman, Hawaii State Consortium for Integrative
Medicine, Honolulu, HI.
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Copyright © 2004 A.D.A.M., Inc
The publisher does not
accept any responsibility for the accuracy of the
information or the consequences arising from the
application, use, or misuse of any of the information
contained herein, including any injury and/or damage to
any person or property as a matter of product liability,
negligence, or otherwise. No warranty, expressed or
implied, is made in regard to the contents of this
material. No claims or endorsements are made for any drugs
or compounds currently marketed or in investigative use.
This material is not intended as a guide to
self-medication. The reader is advised to discuss the
information provided here with a doctor, pharmacist,
nurse, or other authorized healthcare practitioner and to
check product information (including package inserts)
regarding dosage, precautions, warnings, interactions, and
contraindications before administering any drug, herb, or
supplement discussed herein.
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