| Antidiabetic
Medications |
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| Sulfonylureas |
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| Depletions |
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| Coenzyme
Q10 |
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A deficiency of the antioxidant
coenzyme Q10 may be associated with
long-term conditions including heart
disease and high blood pressure. Symptoms
of deficiency include gingivitis, and
weakened immune function.
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| Editorial Note |
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The selected depletions information
presented here identifies some of the
nutrients that may be depleted by certain
medications. The signs and symptoms
associated with nutrient deficiency may
also indicate conditions other than
nutrient deficiency. If you are
experiencing any of the signs or symptoms
mentioned, it does not necessarily mean
that you are nutrient deficient. Nutrient
depletion depends upon a number of
factors, including your medical history,
diet, and lifestyle as well as the length
of time you have been taking the
medication. Please consult your healthcare
provider; he or she can best assess and
address your individual healthcare needs,
and determine if you are at risk for
nutrient depletions from these medications
as well as others not listed here.
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| Supporting Research |
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Chan A, Reichmann H, Kogel A, et al.
Metabolic changes in patients with
mitochondrial myopathies and effects of
coenzyme Q10 therapy. J Neurol.
1998;245(10):681-685.
Folkers K, Morita M, McRee J Jr. The
activities of coenzyme Q10 and vitamin B6
for immune responses. Biochem Biophys
Res Commun. 1993; 28(19391):88-92.
Kamikawa T, Kobayashi A, Yamashita T,
et al. Effects of coenzyme Q10 on exercise
tolerance in chronic stable angina
pectoris. Am J Cardiol.
1985;56(4):247-251.
Kishi T, Kishi H, Watanabe T, Folkers
K. Bioenergetics in clinical medicine. XI.
Studies on coenzyme Q and diabetes
mellitus. J Med.
1976;7(3-4):307-321.
Miyake Y, Shouzu A, Nishikawa M, et al.
Effect of treatment with
3-hydroxy-3-methylglutaryl coenzyme A
reductase inhibitors on serum coenzyme Q10
in diabetic patients. Arzneimittelforschung.
1999;49(4):324-329.
Munkholm H, Hansen HH, Rasmussen K.
Coenzyme Q10 treatment in serious heart
failure. Biofactors.
1999;9(2-4):285-289.
Nakamura R, Littarru GP, Folkers R, et
al. Study of CoQ10-enzymes in gingiva from
patients with periodontal disease and
evidence for a deficiency of coenzyme Q10.
Proc Natl Acad SciUSA.
1974;71(4):1456-1460.
Singh RB, Niaz MA, Rastogi SS, et al.
Effect of hydrosoluble coenzyme Q10 on
blood pressure and insulin resistance in
hypertensive patients with coronary heart
disease. J Hum Hypertens.
1999;13(3):203-208.
Singh RB, Wander GS, Rastogi A, et al.
Randomized, double-blind
placebo-controlled trial of coenzyme Q10
in patients with acute myocardial
infarction. Cardiovasc Drugs Ther.
1998;12(4):347-353.
Watanabe HT. and Folkers, K.
Bioenergetics in clinical medicine. XI.
Studies on CoQ and diabetes mellitus. J.
Med. 7:307-321, 1976.
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| Review
Date: October 2000 |
Reviewed
By: All depletions monographs have
been reviewed by a team of experts
including Derrick M. DeSilva, Jr., MD,
Raritan Bay Medical Center, Perth Amboy,
NJ; Jacqueline A. Hart, MD, Department of
Internal Medicine, Newton-Wellesley
Hospital, Harvard University and Senior
Medical Editor, A.D.A.M., Inc., Boston,
MA; John Hinze, PharmD, NMD, Woodbine, IA;
Ruth Marlin, MD, Medical Director and
Director of Medical Education, Preventive
Medicine Research Institute, Sausalito,
CA; Brian T Sanderoff, PD, BS in Pharmacy,
Clinical Assistant Professor, University
of Maryland School of Pharmacy; President,
Your Prescription for Health, Owings
Mills, MD; Leonard Wisneski, MD, FACP,
George Washington University, Rockville,
MD; Ira Zunin, MD, MPH, MBA, President and
Chairman, Hawaii State Consortium for
Integrative Medicine, Honolulu, HI.
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Copyright © 2004 A.D.A.M., Inc
The
publisher does not accept any
responsibility for the accuracy of the
information or the consequences arising
from the application, use, or misuse of
any of the information contained herein,
including any injury and/or damage to any
person or property as a matter of product
liability, negligence, or otherwise. No
warranty, expressed or implied, is made in
regard to the contents of this material.
No claims or endorsements are made for any
drugs or compounds currently marketed or
in investigative use. This material is not
intended as a guide to self-medication.
The reader is advised to discuss the
information provided here with a doctor,
pharmacist, nurse, or other authorized
healthcare practitioner and to check
product information (including package
inserts) regarding dosage, precautions,
warnings, interactions, and
contraindications before administering any
drug, herb, or supplement discussed
herein.
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