|
| |
| Cholesterol-Lowering
Medications |
|
|
| HMG-CoA
Reductase Inhibitors (Statins) |
|
|
|
|
|
| Depletions |
|
|
| Coenzyme
Q10 |
|
|
A deficiency of the antioxidant coenzyme Q10 may be
associated with long-term conditions including heart
disease and high blood pressure. Symptoms of deficiency
include gingivitis, and weakened immune function.
|
|
|
|
| Editorial
Note |
|
|
The selected depletions information presented here
identifies some of the nutrients that may be depleted by
certain medications. The signs and symptoms associated
with nutrient deficiency may also indicate conditions
other than nutrient deficiency. If you are experiencing
any of the signs or symptoms mentioned, it does not
necessarily mean that you are nutrient deficient.
Nutrient depletion depends upon a number of factors,
including your medical history, diet, and lifestyle as
well as the length of time you have been taking the
medication. Please consult your healthcare provider; he
or she can best assess and address your individual
healthcare needs, and determine if you are at risk for
nutrient depletions from these medications as well as
others not listed here.
|
|
|
|
| Supporting
Research |
|
|
Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous
CoQ10 supplementation prevents ubiquinone reduction
induced by HMG-CoA reductase inhibitors. Mol Aspects
Med. 1994;15(Suppl):S187-S193.
Belichard P, Pruneau D, Zhiri A. Effect of a
long-term treatment with lovastatin or fenofibrate on
hepatic and cardiac ubiquinone levels in cardiomyopathic
hamster. Biochim Biophys Acta.
1993;1169(1):98-102.
Bliznakov EG, Wilkins DJ. Biochemical and clinical
consequences of inhibiting coenzyme Q10 biosynthesis by
lipid-lowering HMG-CoA reductase inhibitors (statins): A
critical review. Adv Ther. 1998;15(4):218-228.
Chan A, Reichmann H, Kogel A, et al. Metabolic
changes in patients with mitochondrial myopathies and
effects of coenzyme Q10 therapy. J Neurol.
1998;245(10):681-685.
De Pinieux G, et al. Lipid-lowering drugs and
mitochondrial function: effects of HMG-CoA reductase
inhibitors on serum ubiquinone and blood lactate/pyruvate
ratio. Br J Clin Pharmacol. 1996;42(3):333-337.
Folkers K, Langsjoen P, Willis R, et al. Lovastatin
decreases coenzyme Q levels in humans. Proc Natl Acad
Sci USA. 1990;87(22):8931-8934.
Folkers K, Morita M, McRee J Jr. The activities of
coenzyme Q10 and vitamin B6 for immune responses. Biochem
Biophys Res Commun. 1993; 28(19391):88-92.
Ghirlanda G, Oradei A, Manto A, et al. Evidence of
plasma CoQ10-lowering effect of HMG-CoA reductase
inhibitors: a double-blind, placebo-controlled study. J
Clin Pharmacol. 1993;33(3):226-229.
Hanaki Y, Sugiyama S, Ozawa T, Ohno M. Coenzyme Q10
and coronary artery disease. Clin Invest.
1993;71(8 Suppl):S112-S115.
Kaikkonen J, Nyyssonen K, Tuomainen TP, et al.
Determinants of plasma coenzyme Q10 in humans. FEBS Lett.
1999;443(2):163-166.
Kamikawa T, Kobayashi A, Yamashita T, et al. Effects
of coenzyme Q10 on exercise tolerance in chronic stable
angina pectoris. Am J Cardiol.
1985;56(4):247-251.
Laaksonen R, Ojala JP, Tikkanen MJ, Himberg JJ. Serum
ubiquinone concentrations after short- and long-term
treatment with HMG-CoA reductase inhibitors. Eur J
Clin Pharmacol. 1994;46(4):313-317.
Mortensen SA, Leth A, Agner E, Rohde M. Dose-related
decrease of serum coenzyme Q10 during treatment with
HMG-CoA reductase inhibitors. Mol Aspects Med.
1997;18(Suppl):S137-S144.
Munkholm H, Hansen HH, Rasmussen K. Coenzyme Q10
treatment in serious heart failure. Biofactors.
1999;9(2-4):285-289.
Nakamura R, Littarru GP, Folkers R, et al. Study of
CoQ10-enzymes in gingiva from patients with periodontal
disease and evidence for a deficiency of coenzyme Q10. Proc
Natl Acad SciUSA. 1974;71(4):1456-1460.
Singh RB, Niaz MA, Rastogi SS, et al. Effect of
hydrosoluble coenzyme Q10 on blood pressure and insulin
resistance in hypertensive patients with coronary heart
disease. J Hum Hypertens. 1999;13(3):203-208.
Singh RB, Wander GS, Rastogi A, et al. Randomized,
double-blind placebo-controlled trial of coenzyme Q10 in
patients with acute myocardial infarction. Cardiovasc
Drugs Ther. 1998;12(4):347-353.
Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma
coenzyme Q (ubiquinone) concentrations in patients with
simvastatin. J Clin Pathol.
1993;46(11):1055-1057.
|
|
|
| Review Date: October
2000 |
Reviewed By: All
depletions monographs have been reviewed by a team of
experts including Derrick M. DeSilva, Jr., MD, Raritan
Bay Medical Center, Perth Amboy, NJ; Jacqueline A. Hart,
MD, Department of Internal Medicine, Newton-Wellesley
Hospital, Harvard University and Senior Medical Editor,
A.D.A.M., Inc., Boston, MA; John Hinze, PharmD, NMD,
Woodbine, IA; Ruth Marlin, MD, Medical Director and
Director of Medical Education, Preventive Medicine
Research Institute, Sausalito, CA; Brian T Sanderoff,
PD, BS in Pharmacy, Clinical Assistant Professor,
University of Maryland School of Pharmacy; President,
Your Prescription for Health, Owings Mills, MD; Leonard
Wisneski, MD, FACP, George Washington University,
Rockville, MD; Ira Zunin, MD, MPH, MBA, President and
Chairman, Hawaii State Consortium for Integrative
Medicine, Honolulu, HI.
|
|
Copyright © 2004 A.D.A.M., Inc
The publisher does not
accept any responsibility for the accuracy of the
information or the consequences arising from the
application, use, or misuse of any of the information
contained herein, including any injury and/or damage to
any person or property as a matter of product liability,
negligence, or otherwise. No warranty, expressed or
implied, is made in regard to the contents of this
material. No claims or endorsements are made for any
drugs or compounds currently marketed or in
investigative use. This material is not intended as a
guide to self-medication. The reader is advised to
discuss the information provided here with a doctor,
pharmacist, nurse, or other authorized healthcare
practitioner and to check product information (including
package inserts) regarding dosage, precautions,
warnings, interactions, and contraindications before
administering any drug, herb, or supplement discussed
herein.
|
|
|
|
 |
|
| |
|
