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| Psychotherapeutic
Medications |
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| Thioxanthene Derivatives |
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| Depletions |
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| Coenzyme
Q10 |
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A deficiency of the antioxidant coenzyme Q10
may be associated with long-term conditions
including heart disease and high blood pressure.
Symptoms of deficiency include gingivitis, and
weakened immune function.
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| Vitamin
B2 (Riboflavin) |
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Symptoms of vitamin B2 deficiency
may include cracks at the corners of the mouth,
inflammation of the skin, growth retardation,
and impaired wound healing.
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| Editorial Note |
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The selected depletions information presented
here identifies some of the nutrients that may
be depleted by certain medications. The signs
and symptoms associated with nutrient deficiency
may also indicate conditions other than nutrient
deficiency. If you are experiencing any of the
signs or symptoms mentioned, it does not
necessarily mean that you are nutrient
deficient. Nutrient depletion depends upon a
number of factors, including your medical
history, diet, and lifestyle as well as the
length of time you have been taking the
medication. Please consult your healthcare
provider; he or she can best assess and address
your individual healthcare needs, and determine
if you are at risk for nutrient depletions from
these medications as well as others not listed
here.
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| Supporting Research |
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Chan A, Reichmann H, Kogel A, et al.
Metabolic changes in patients with mitochondrial
myopathies and effects of coenzyme Q10 therapy. J
Neurol. 1998;245(10):681
Fauci, A. ed. et. al. Harrison's
Principles of Internal Medicine. Fourteenth
Edition. New York, Mc-Graw-Hill Companies Health
Professional Division, 1998.
Folkers K, Morita M, McRee J Jr. The
activities of coenzyme Q10 and vitamin B6 for
immune responses. Biochem Biophys Res Commun.
1993; 28(19391):88.
Folkers, K. Basic chemical research on
coenzyme Q-10 and integrated clinical research
on therapy of diseases, in Coenzyme Q, G.
Lenaz, ed., John Wiley & Sons, 1985.
International Life Sciences Institute, Present
Knowledge in Nutrition. Seventh Edition.
Washington, DC, ILSI Press, 1996.
Kamikawa T, Kobayashi A, Yamashita T, et al.
Effects of coenzyme Q10 on exercise tolerance in
chronic stable angina pectoris. Am J Cardiol.
1985;56(4):247
Munkholm H, Hansen HH, Rasmussen K. Coenzyme
Q10 treatment in serious heart failure. Biofactors.1999;9(2)
Nakamura R, Littarru GP, Folkers R, et al.
Study of CoQ10-enzymes in gingiva from patients
with periodontal disease and evidence for a
deficiency of coenzyme Q10. Proc Natl Acad
SciUSA. 1974;71(4):1456-1460.
National Research Council, Recommended
Dietary Allowances. Tenth Edition.
Washington, DC, National Academy Press, 1989.
Pinto, J. et al. Inhibition of riboflavin
metabolism in rat tissues by chlorpromazine,
imipramine and amitriptyline. J Clin Invest.
1981;67:1, 500.
Singh RB, Niaz MA, Rastogi SS, et al. Effect
of hydrosoluble coenzyme Q10 on blood pressure
and insulin resistance in hypertensive patients
with coronary heart disease. J Hum Hypertens.
1999;13(3):203
Singh RB, Wander GS, Rastogi A, et al.
Randomized, double-blind placebo-controlled
trial of coenzyme Q10 in patients with acute
myocardial infarction. Cardiovasc Drugs Ther.
1998;12(4):347-353.
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| Review Date: October
2000 |
Reviewed By: All
depletions monographs have been reviewed by a
team of experts including Derrick M. DeSilva,
Jr., MD, Raritan Bay Medical Center, Perth
Amboy, NJ; Jacqueline A. Hart, MD, Department of
Internal Medicine, Newton-Wellesley Hospital,
Harvard University and Senior Medical Editor,
A.D.A.M., Inc., Boston, MA; John Hinze, PharmD,
NMD, Woodbine, IA; Ruth Marlin, MD, Medical
Director and Director of Medical Education,
Preventive Medicine Research Institute,
Sausalito, CA; Brian T Sanderoff, PD, BS in
Pharmacy, Clinical Assistant Professor,
University of Maryland School of Pharmacy;
President, Your Prescription for Health, Owings
Mills, MD; Leonard Wisneski, MD, FACP, George
Washington University, Rockville, MD; Ira Zunin,
MD, MPH, MBA, President and Chairman, Hawaii
State Consortium for Integrative Medicine,
Honolulu, HI.
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Copyright © 2004 A.D.A.M., Inc
The publisher does
not accept any responsibility for the accuracy
of the information or the consequences arising
from the application, use, or misuse of any of
the information contained herein, including any
injury and/or damage to any person or property
as a matter of product liability, negligence, or
otherwise. No warranty, expressed or implied, is
made in regard to the contents of this material.
No claims or endorsements are made for any drugs
or compounds currently marketed or in
investigative use. This material is not intended
as a guide to self-medication. The reader is
advised to discuss the information provided here
with a doctor, pharmacist, nurse, or other
authorized healthcare practitioner and to check
product information (including package inserts)
regarding dosage, precautions, warnings,
interactions, and contraindications before
administering any drug, herb, or supplement
discussed herein.
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