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| Anti-inflammatory Medications |
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| Salicylates |
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 | Aspirin
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(Anacin®[OTC];
Arthritis Foundation® Pain Reliever [OTC];
Ascriptin®[OTC]; Aspergum®[OTC]; Asprimox®[OTC];
Bayer® Aspirin [OTC]; Bayer® Buffered Aspirin
[OTC]; Bayer® Low Adult Strength [OTC]; Bufferin®[OTC];
Buffex®[OTC]; Cama® Arthritis Pain Reliever [OTC];
Easprin®; Ecotrin® Low Adult Strength [OTC];
Ecotrin®[OTC]; Empirin®[OTC]; Extra Strength
Adprin-B®[OTC]; Extra Strength Bayer® Enteric 500
Aspirin [OTC]; Extra Strength Bayer® Plus [OTC];
Halfprin® 81®[OTC]; Heartline®[OTC]; Regular
Strength Bayer® Enteric 500 Aspirin [OTC]; St
Joseph® Adult Chewable Aspirin [OTC]; ZORprin®) |
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| Depletions |
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| Iron |
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Depleted levels of iron may lead to anemia and weakened
immune function. In the event of anemia, symptoms include
dizziness, fatigue, shortness of breath, pale skin color, and
possibly irregular heartbeat.
Note: Iron loss is secondary to bleeding.
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| Potassium |
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Symptoms of potassium deficiency include loss of appetite,
nausea, drowsiness, feelings of apprehension, excessive thirst,
irrational behavior, fatigue, muscle pain and weakness (usually
of the lower limbs); severe cases may lead to irregular
heartbeat.
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| Vitamin
B9 (Folic Acid) |
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Low levels of folic acid have been linked to anemia, heart
disease, and birth defects.
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| Vitamin
C (Ascorbic Acid) |
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Vitamin C deficiency may include bruising, fever, anemia,
emotional changes, swollen and bleeding gums, fatigue, lethargy,
jaundice (yellowing of the skin and eyes), increased
susceptibility to infections, slow wound healing, and swelling
of the lower limbs. Severe deficiency leads to scurvy, a
disorder that affects muscles and bones and is potentially
fatal. However, scurvy is rare these days because of the wide
availability of vitamin C from dietary sources.
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| Editorial Note |
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The selected depletions information presented here identifies
some of the nutrients that may be depleted by certain
medications. The signs and symptoms associated with nutrient
deficiency may also indicate conditions other than nutrient
deficiency. If you are experiencing any of the signs or symptoms
mentioned, it does not necessarily mean that you are nutrient
deficient. Nutrient depletion depends upon a number of factors,
including your medical history, diet, and lifestyle as well as
the length of time you have been taking the medication. Please
consult your healthcare provider; he or she can best assess and
address your individual healthcare needs, and determine if you
are at risk for nutrient depletions from these medications as
well as others not listed here.
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| Supporting Research |
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Ames BN. Micronutrient deficiencies: A major cause of DNA
damage. Ann NY Acad Sci. 2000;889:87-106.
Carr AC, Frei B. Toward a new recommended dietary allowance
for vitamin C based on antioxidant and health effects in humans.
Am J Clin Nutr 1999;69:1086-1087.
Coffey G. and Wilson CWM. Ascorbic acid deficiency and
aspirin-induced haematemesis. BM J. 1975;1:208.
Covington T, ed. Nonprescription Drug Therapy Guiding
Patient Self-Care. St. Louis, Mo: Facts and Comparisons;
1999: 467-545.
Lawrence, VA, et al. Aspirin and folate binding: in vivo and
in vitro studies of serum binding and urinary excretion of
endogenous folate. J Lab Clin Med. 1984;103:944-948.
Leonards JH. and Levy G. Gastrointestinal blood loss during
prolonged aspirin administration. N Engl J Med.
1973;289:1020-1022.
National Research Council. Recommended Dietary Allowances.
10th ed. Washington, DC: National Academy Press;
1989.
Selhub, J, et al. Inhibition of folate enzymes by
sulfasalazine. J Clin Invest. 1978;61:221-224.
Smith MJH. and Smith PK. eds. The Salicylates: A Critical
Bibliographic Review. New York, Interscience, 1966.
Wilson JD. Vitamin deficiency and excess. In: Fauci AS,
Braunwald E, Isselbacher KJ, et al, eds. Harrison's
Principles of Internal Medicine. 14th ed. New
York: McGraw-Hill Companies Health Professional Division;
1998:483-485.
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| Review Date: October 2000 |
Reviewed By: All depletions
monographs have been reviewed by a team of experts including
Derrick M. DeSilva, Jr., MD, Raritan Bay Medical Center, Perth
Amboy, NJ; Jacqueline A. Hart, MD, Department of Internal
Medicine, Newton-Wellesley Hospital, Harvard University and
Senior Medical Editor, A.D.A.M., Inc., Boston, MA; John Hinze,
PharmD, NMD, Woodbine, IA; Ruth Marlin, MD, Medical Director and
Director of Medical Education, Preventive Medicine Research
Institute, Sausalito, CA; Brian T Sanderoff, PD, BS in Pharmacy,
Clinical Assistant Professor, University of Maryland School of
Pharmacy; President, Your Prescription for Health, Owings Mills,
MD; Leonard Wisneski, MD, FACP, George Washington University,
Rockville, MD; Ira Zunin, MD, MPH, MBA, President and Chairman,
Hawaii State Consortium for Integrative Medicine, Honolulu, HI.
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Copyright © 2004 A.D.A.M., Inc
The publisher does not accept any
responsibility for the accuracy of the information or the
consequences arising from the application, use, or misuse of any
of the information contained herein, including any injury and/or
damage to any person or property as a matter of product
liability, negligence, or otherwise. No warranty, expressed or
implied, is made in regard to the contents of this material. No
claims or endorsements are made for any drugs or compounds
currently marketed or in investigative use. This material is not
intended as a guide to self-medication. The reader is advised to
discuss the information provided here with a doctor, pharmacist,
nurse, or other authorized healthcare practitioner and to check
product information (including package inserts) regarding
dosage, precautions, warnings, interactions, and
contraindications before administering any drug, herb, or
supplement discussed herein.
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