| Spirulina |
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| Also Known As: |
Blue-green algae,Spirulina
species (spp.) |
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| Overview |
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Spirulina is a type of blue-green algae found in most lakes
and ponds. It has been consumed for thousands of years by
Mexican (Aztecs, Mayans), African, and Asian peoples. Spirulina
is considered a complete protein because well over half of it
consists of amino acids -- the building blocks of protein. It is
also a rich source of other nutrients including B complex
vitamins, beta-carotene, vitamin E, carotenoids, manganese,
zinc, copper, iron, selenium, and gamma linolenic acid (an
essential fatty acid). In fact, at least one laboratory study
has demonstrated that the iron level in spirulina is equivalent
to that contained in beef. Because of its apparent ability to
stimulate the immune system, spirulina may have antiviral and
anticancer effects. Test tube and animal studies suggest that
spirulina may also help protect against harmful allergic
reactions. More research is needed to fully understand how
spirulina truly benefits people.
Interestingly, spirulina has been used in Russia to treat the
victims, especially children, of the nuclear disaster at
Chernobyl. In these children, whose bone marrow had been damaged
from radiation exposure, spirulina seemed to boost the immune
system.
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| Uses |
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Immune Enhancement
Animal and test tube studies suggest that spirulina
increases production of antibodies, cytokines (infection
fighting proteins), and other cells that improve immunity and
help ward off infection and chronic illnesses such as cancer.
Protein Supplement
Amino acids make up 62% of spirulina. Because it is a rich
source of protein and other nutrients, spirulina has been used
traditionally as a nutritional supplement by people who cannot
obtain sufficient calories or protein through diet alone and by
those whose nutritional requirements are higher than normal,
such as athletes.
Anemia
Animal studies suggest that spirulina promotes hematopoiesis
(formation and development of red blood cells). This is thought
to be due to the high levels of iron present in this food
supplement.
Allergic Reactions
Animal and test tube studies suggest that spirulina may
protect against allergic reactions by preventing the release of
histamines (substances that contribute to allergy symptoms such
as a runny nose, watery eyes, hives, and soft-tissue swelling).
Whether these preliminary studies will translate into benefit
for people with allergies is not known.
Antibiotic-related Illnesses
Although antibiotics destroy unwanted organisms in the body,
they may also kill "good" bacteria called probiotics
(such as Lactobacillus acidophilus) which sometimes
results in diarrhea. In test tubes, spirulina has promoted the
growth of L. acidophilus and other probiotics. Whether
this positive laboratory finding will translate into protection
from antibiotic-related diarrhea is not clear at this time.
Infection
Test tube studies suggest that spirulina has activity
against herpes, influenza, cytomeglovirus, and human
immunodeficiency virus (HIV). Whether this laboratory finding
will prove beneficial for people in treating these infections is
not clear.
Oral Cancer
In one study, 87 people who chewed tobacco and had a
precancerous lesion known as leukoplakia were randomly assigned
to receive Spirulina fusiformis or placebo. Lesions were
significantly more likely to disappear in the spirulina group
than in the placebo group. More research in this area will be
very helpful.
Liver Disorders
There is some preliminary evidence that spirulina may help
protect against liver damage and cirrhosis (liver failure) in
those with chronic hepatitis. More research is needed in this
area.
Other
Spirulina is also contained in some skin care products due
to its moisturizing and tightening properties, and components
derived from spirulina may have properties to help reduce
inflammation in, for example, arthritis. More research is needed
in this latter area.
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| Dietary Sources |
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Spirulina is a microscopic algae that flourishes in warm
climates and warm alkaline water. It is available dried and
freeze-dried.
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| Available Forms |
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Spirulina is available in pill or powder form. Most of the
spirulina consumed in the United States is cultivated in a
laboratory. There are many different spirulina species (spp.),
only some of which are identified on labels of commercially
available products. Spirulina maxima (cultivated in
Mexico) and Spirulina platensis (cultivated in
California) are the most popular.
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| How to Take It |
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Pediatric
Although spirulina has been used in children (e.g. victims of
the Chernobyl nuclear accident), the safe and effective dose for
those under 18 has not yet been established.
Adult
Consult an appropriate health care provider for the correct
dosage of spirulina. A standard dosage of spirulina is 4 to 6
tablets (500 mg each) per day.
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| Precautions |
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Because of the potential for side effects and interactions
with medications, dietary supplements should be taken only under
the supervision of a knowledgeable healthcare provider.
There are no known toxicities associated with spirulina,
based on testing of high doses of this supplement in animals.
Spirulina has even been tested in pregnant animals and no risk
to either maternal or fetal rats and mice was discovered.
However, it is not known whether this will translate to humans.
Therefore, it is safest to talk with your health care provider
before taking spirulina if you are pregnant or breast-feeding.
In addition, those with a metabolic condition called
phenylketonuria (PKU) should discuss potential use of spirulina
with their healthcare provider. This unusual condition is
characterized by an inability to metabolize the amino acid
phenylalanine. Spirulina is rich in all amino acids, including
phenylalanine. Most likely, it is okay for those with PKU to use
this supplement because the presence of all of the other
essential amino acids balances the high levels of phenylalanine.
However, it is best and safest to check with your healthcare
provider if you have PKU.
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| Possible Interactions |
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There are no reports in the scientific literature to suggest
that spirulina interacts with any conventional medications.
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| Supporting Research |
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Annapurna VV, Deosthale YG, Bamji MS. Spirulina as a source
of vitamin A. Plant Foods Hum Nutr. 1991;41:125–134.
Ayehunie S, Belay A, Baba TW, Ruprecht RM. Inhibition of
HIV-1 replication by an aqueous extract of Spirulina
platensis (Arthrospira plantensis). J Acquir
Immune Defic Syndr Hum Retrovirol. 1998;18(1):7-12.
Blinkova LP, Gorobets OB, Baturo AP. [Biological activity of
Spirulina.] Zh Mikrobiol Epidemiol Immunobiol. 2001;(2):
114-118.
Chamorro G, Salazar M, Favila L, Bourges H. Pharmacology and
toxicology of Spirulina alga. Rev Invest Clin.
1996;48:389–399.
Gonzalez R, Rodriguez S, Romay C, et al. Anti-inflammatory
activity of phycocyanin extract in acetic acid-induced colitis
in rats. Pharmacol Res. 1999;39:1055–1059.
Gorban EM, Orynchak MA, Virstiuk NG, Kuprash LP,
Panteleimonov TM, Sharabura LB. [Clinical and experimental study
of spirulina efficacy in chronic diffuse liver diseases.] Lik
Sprava. 2000(6):89-93.
Hayashi K, Hayashi T, Kojima I. A natural sulfated
polysaccharide, calcium spirulan, isolated from Spirulina
platensis: in vitro and ex vivo evaluation of anti-herpes
simplex virus and anti-human immunodeficiency virus activities. AIDS
Res Hum Retroviruses. 1996;12:1463–1471.
Hayashi O, Hirahashi T, Katoh T, Miyajima H, Hirano T,
Okuwaki Y. Class specific influence of dietary Spirulina
platensis on antibody production in mice. J Nutr Sci
Vitaminol. 1998;44(6):841-851.
Kapoor R, Mehtu U. Iron status and growth of rats fed
different dietary iron sources. Plan Foods Hum Nutr.
1993; 44(1):29-34.
Kim HM, Lee EH, Cho HH, Moon YH. Inhibitory effect of mast
cell-mediated immediate-type allergic reactions in rats by
spirulina. Biochem Pharmacol. 1998;55(7);1071-1076.
Mao TK, Van De Water J, Gershwin ME. Effect of spirulina on
the secretion of cytokines from peripheral blood mononuclear
cells. J Medicinal Food. 2000;3(3):135-139.
Mathew B, Sankaranarayanan R, Nair PP, et al. Evaluation of
chemoprevention of oral cancer with Spirulina fusiformis.
Nutr Cancer. 1995;24:197–202.
Parada JL, Zulpa de Caire G, Zaccaro de Mule MC, Storni de
Cano MM. Lactic acid bacteria growth promoters from Spirulina
platensis. Int J Food Microbiol. 1998;45(3):225-228.
Puyfoulhoux G, Rouanet JM, Besancon P, Baroux B, Baccou JC,
Caporiccio B. Iron availability from iron-fortified spirulina by
an in vitro digestion/Caco-2 cell culture model. J Agric Food
Chem. 2001;49(3):1625-1629.
Qureshi MA, Garlich JD, Kidd MT. Dietary Spirulina
platensis enhances humoral and cell-mediated immune
functions in chickens. Immunopharmacol Immunotoxicol.
1996;18:465–476.
Reddy CM, Bhat VB, Kiranmai G, Reddy MN, Reddanna P,
Madyastha KM. Selective inhibition of cyclooxygenase-2 by C-phocyanin,
a biliprotein from Spirulina platensis. Biochem Ciophys Res
Commun. 2000;277(3):599-603.
Romay C, Armesto J, Remirez D, Gonzalez R, Ledon N, Garcia I.
Antioxidant and anti-inflammatory properties of C-phycocyanin
from blue-green algae. Inflamm Res. 1998;47:36–41.
Salazar M, Martinez E, Madrigal E, Ruiz LE, Chamorro GA.
Subchronic toxicity study in mice fed Spirulina maxima. J
Ethnopharmacol. 1998;62:235–241.
Torres-Duran PV, Miranda-Zamora R, Paredes-Carbajal MC,
Mascher D, Ble-Castillo J, Diaz-Zagoya JC, Juarez Oropeza MA.
Studies on the preventive effect of Spirulina maxima on
fatty liver development induced by carbon tetrachloride, in the
rat. J Ethnopharmacol. 1999;64(2):141-147.
Yank HN, Lee EH, Kim HM. Spirulina platensis inhibits
anaphylactic reaction. Life Sci. 1997;61(13):1237-1244.
Zozulia IS, Iurchenko AV. [The adaptive potentials of those
who worked in the cleanup of the aftermath of the accident at
the Chernobyl Atomic Electric Power Station under the influence
of different treatment methods] [Ukranian]. Lik Sprava. 2000;(3-4):18-21.
Abstract.
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| Review Date: April
2002 |
Reviewed By: Participants
in the review process include: Ruth DeBusk, RD, PhD, Editor,
Nutrition in Complementary Care, Tallahassee, FL; Jacqueline A.
Hart, MD, Department of Internal Medicine, Newton-Wellesley
Hospital, Harvard University and Senior Medical Editor
Integrative Medicine, Boston, MA; Gary Kracoff, RPh (Pediatric
Dosing section February 2001), Johnson Drugs, Natick, Ma; Steven
Ottariono, RPh (Pediatric Dosing section February 2001),
Veteran's Administrative Hospital, Londonderry, NH. All
interaction sections have also been reviewed by a team of
experts including Joseph Lamb, MD (July 2000), The Integrative
Medicine Works, Alexandria, VA;Enrico Liva, ND, RPh (August
2000), Vital Nutrients, Middletown, CT; Brian T Sanderoff, PD,
BS in Pharmacy (March 2000), Clinical Assistant Professor,
University of Maryland School of Pharmacy; President, Your
Prescription for Health, Owings Mills, MD; Ira Zunin, MD, MPH,
MBA (July 2000), President and Chairman, Hawaii State Consortium
for Integrative Medicine, Honolulu, HI.
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Copyright © 2004 A.D.A.M., Inc
The publisher does not accept any
responsibility for the accuracy of the information or the
consequences arising from the application, use, or misuse of any
of the information contained herein, including any injury and/or
damage to any person or property as a matter of product
liability, negligence, or otherwise. No warranty, expressed or
implied, is made in regard to the contents of this material. No
claims or endorsements are made for any drugs or compounds
currently marketed or in investigative use. This material is not
intended as a guide to self-medication. The reader is advised to
discuss the information provided here with a doctor, pharmacist,
nurse, or other authorized healthcare practitioner and to check
product information (including package inserts) regarding
dosage, precautions, warnings, interactions, and
contraindications before administering any drug, herb, or
supplement discussed herein.
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